Is inositol hexanicotinate effective in lowering cholesterol?

already exists.

Would you like to merge this question into it?

already exists as an alternate of this question.

Would you like to make it the primary and merge this question into it?

exists and is an alternate of .

In response to below, NO. The latest data we have shows that Inositol Hexanicotinate doe not affect HDL, LDL or TGs at all. It was "presumed" to work, but this has since been disproven. All the articles below are essentially speculation. The FDA should actually pull the drug off the market since the only thing it actually does help is vitamin B deficiency (which is rare). People take it to avoid flushing, but since it doesn't help with lipids at all, it doesn't matter that it avoids flushing - it does this because it's not actually working.

If you want to lower your LDL and TG and raise your HDL, take immediate release niacin (OTC), slow-release niacin (Slo-Niacin - OTC) or extended-release niacin (Niaspan - Rx). Ask your pharmacist for more information.

-the most recent published information I could find upon cursory search is Meyers CD, Carr MC, Park S, Brunzell JD. Varying cost and free nicotinic acid content in over-the-counter niacin preparations for dyslipidemia. Ann Intern Med. 2003;139(12):996-1002.

Yes, based on the open scientific literature it lowers high cholesterol better than does plain Niacin. Basically triglycerides (VLDL) are reduced and HDL is increased (a very good thing). You can expect your total cholesterol to approach a more normal value.

The decrease expected (dTC) from your initial total cholesterol level (TC) varies according to ones' body weight (Wgt) by the equation:

dTC = 0.95(TC) - 0.39(Wgt) - 90 (from Abram Hoffer M.D. Ph.D)

Dr Hoffer notes that total cholesterol levels will rise if the initial level was abnormally low for the patient's body weight (here a negative dTC is an increase).

Supporting data:

"IHN is more effective than niacin in its hypocholesterolemic,
antihypertensive and lipotropic effects"
Welsh AL, Eade M. Inositol hexanicotinate for improved nicotinic acid therapy.
Int Record Med 1961;174:9-15.

"significant lipid-lowering effects of IHN at doses of 400 mg 3-4 times daily"
Dorner V, Fischer FW. The influence of m-inositol hexanicotinate ester on the serum lipids and lipoproteins. Arzneim-Forsch 1961;11:110-113.

Sommer H. Nicotinic acid levels in the blood and fibrinolysis under the influence of the hexanicotinic ester of m-inositol. Arzneim Forsch. 1975;15:1337

"IHN was found to be more effective than niacin in reducing hypercholesterolemia"
El-Enein AMA, Hafez YS, Salem H, Abdel M. The role of nicotinic acid and inositol hexaniacinate as anticholesterolemic and antilipemic agents.
Nutr Reports Int 1983;28:899-911.

"Derivatives of niacin have been examined for their ability to alter lipid levels as well as niacin. It would be advantageous if the niacin vasodilation (flush) were eliminated or removed. The main disadvantage of the niacin derivatives will be cost. Inositol hexanicotinate is an ester of inositol and niacin. In the body it is slowly hydrolyzed releasing both of these important nutrients. The ester is more effective than niacin in lowering cholesterol and triglyceride levels, Abou El-Enein, Hafez, Salem and Abdel (1983). I have used this compound, Linodil, available in Canada but not the U.S.A. (at the time this paper was written) for thirty years for patients who can not or will not tolerate the flush. It is very gentle, effective, and can be tolerated by almost every person who uses it."
From: Niacin, Coronary Disease and Longevity by Abram Hoffer, M.D., Ph.D.

BIAM (a database designed for health professionals) entry:
Alternate Names:
"inositol hexanicotinate"
"inositol hexaniacinate"
"hexanicotinoyl inositol"
"inositol hexanicotinate"
"mesoinositol hexanicotinate"

Trade Names:
23 people found this useful

How do you lower cholesterol?

First, make dietary changes. Eat more fish containing omega 3 fatty acids, such as salmon or sardines (but please be careful with fish, everyday eating fish gets riskier and r

How do you lower your cholesterol?

There are some simple ways to lower your cholesterol : . Eating a healthy diet (avoid unnecessary carbohydrates, and try to avoid hydrogenated fats, whether they be from an

How do I lower my cholesterol?

There are a couple of things that you can do to lower cholesterol . The most common solution that the current medical establishment currently uses is statin drugs. Unfortunat

What is inositol?

Inositol, also known as phytic acid, is a phytochemical found in bran from corn, oats, rice, rye and wheat, nuts, soybeans and soy products (tofu, soy milk, edamame, etc.). It

What is the difference between inositol hexanicotinate and inositol hexaniacinate?

There is no difference. These are but two of many names for the same compound. Here are a couple of lists all the names (that I know of) for "IHN"... Alternate Names: "

Is flush free niacin inositol hexanicotinate the same as long acting niacin?

No. Flush-free niacin is niacin (nicotinic acid) that has been encapsulated to make it dissolve slowly. It is sold as "Niaspan" and is a prescription drug. Inositol hexanicoti

Why lower cholesterol?

An abundance of low-density lipoproteins (LDLs) is dangerous because it contributes to a condition called atherosclerosis, or plaques in the coronary arteries. High LDLs cause

How to lower cholesterol?

You can bring your cholesterol levels down through diet and exercise. Keep a heart healthy diet. There are plenty of tips available on the Internet to help you choose the ri

Will not eating cholesterol lower your cholesterol?

No, actually, it will not. Your body needs cholesterol to do a great number of things, and if you are not getting it from the foods you eat, your body will make its own. There

What do you do to lower your cholesterol?

One of the best ways to lower your cholesterol is to change your diet. Avoid saturated fats, increase your fibre intake, eat more fruits and vegetables, eat fish that contain